Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 312-314
- https://doi.org/10.1021/jm00212a028
Abstract
The synthesis of the 2,4-diamino analogue of riboflavin [potential tumor chemotherapeutic agent] is described. Inhibition analysis in a microbial assay system [Lactobacillus leichmannii] indicated that this compound has a weak antifolate activity that could be overcome with a minimal amount of folinic acid, but at higher concentrations both folinic acid and riboflavin were required for the reversal of its inhibitory effect.This publication has 2 references indexed in Scilit:
- Synthesis of Compounds Related to Thymine. II. Effect of Thymine Antagonists on the Biosynthesis of DNAJournal of the American Chemical Society, 1955
- THE UTILIZATION OF ANTIMETABOLITES IN THE STUDY OF BIOCHEMICAL PROCESSES IN LIVING ORGANISMSAnnals of the New York Academy of Sciences, 1950