Effect of Graded Compression of the Renal Artery on Water and Solute Excretion

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Abstract
The effects of acute reduction in renal circulation on water and total solute excretion were studied in unanesthetized dogs during graded unilateral renal arterial compression. Urine was collected separately from each kidney and the contralateral kidney served as the control during the compression periods. When urines were dilute, renal arterial compression reduced urine flow and solute excretion by a fraction equal to the fractional reduction of glomerular filtration, while urine concentration did not change. When urines were concentrated, compression reduced urine flow by a smaller fraction, concentration fell somewhat, and total solute excretion fell again proportionately to the same degree as the glomerular filtration. Filtration rates varied between 25-100% of control. It is concluded that acute reductions in renal circulation do not increase urine concentration.

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