EFFECTS ON THE PERINEAL SWELLING AND ON THE MENSTRUAL CYCLE OF SINGLE INJECTIONS OF COMBINATIONS OF ESTRADIOL BENZOATE AND PROGESTERONE GIVEN TO BABOONS IN THE FIRST PART OF THE CYCLE1

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Abstract
Inhibition of the ovary by combinations of estradiol and progesterone, simultaneously administered, is described. 5 mg. of estradiol benzoate and 20 mg. of progesterone caused the turgescent perineum to return to rest by the 9th to 10th day in 4 baboons; cystic follicles were present in the ovaries. In 1 animal bleeding was premature and the cycle was shortened. In 3 other animals the perineum began to swell again after the induced turgescence, and bleeding occurred in 2 on the 32nd day of the cycle while the perineum was still turgescent; in the remaining animal the cycle was prolonged by 12 days. Dosages of 5 mg. of estradiol benzoate and 10 mg. of progesterone lengthened the cycle by 17 days. Smaller dosages elicited a variety of responses but in general the cycle was shortened. Bleeding induced by 20 mg. of progesterone in the early cycle could be inhibited by simultaneous adm. of 5 mg. of estradiol benzoate. Ten mg. of progesterone together with 5 mg. of estradiol benzoate produced a result similar to that obtained with estradiol. In 3 of 4 animals injected with 5 mg. of estradiol benzoate and 20 mg. of progesterone cystic ovaries were induced within 24-34 days.