Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin
- 2 January 2003
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 17 (3) , 1-22
- https://doi.org/10.1096/fj.02-0247fje
Abstract
SPECIFIC AIMSHair follicle (HF) morphogenesis and hair cycling are controlled by complex bidirectional ectodermal–mesenchymal interactions and are regulated by a complex balance between a wide variety of stimulatory and inhibitory growth factors. We explored the role of TGF/BMP family member, activin, and its antagonist, follistatin, in hair follicle development and cycling.PRINCIPAL FINDINGS1. Follistatin mRNA is expressed in the hair follicle epithelium whereas activin βA expression predominates in the hair follicle mesenchymeTo ascertain whether follistatin and activin are involved in the control of hair follicle development, we first characterized the expression of follistatin and activin βA mRNA in the back skin of mice at embryonic day (E) E18.5 by in situ hybridization. Follistatin transcripts were detected in the epithelial hair placode, hair matrix, outer root sheath keratinocytes, and interfollicular epidermis whereas activin βA message was mainly visible in developing dermal papilla cells.2. Ac...Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (DFG, Pa345/6-3)
- National Institutes of Health (HD32067)
This publication has 51 references indexed in Scilit:
- Reorganization of hair follicles in human skin organ culture induced by cultured human follicle‐derived cellsExperimental Dermatology, 2005
- Molecular Mechanisms Regulating Hair Follicle DevelopmentJournal of Investigative Dermatology, 2002
- Modulation of BMP Signaling by Noggin is Required for Induction of the Secondary (Nontylotrich) Hair FolliclesJournal of Investigative Dermatology, 2002
- Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tablesExperimental Dermatology, 2001
- Noggin is required for induction of the hair follicle growth phase in postnatal skinThe FASEB Journal, 2001
- Controls of Hair Follicle CyclingPhysiological Reviews, 2001
- Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicleThe EMBO Journal, 2000
- The Biology of Hair FolliclesNew England Journal of Medicine, 1999
- The TGF-β2 Isoform Is Both a Required and Sufficient Inducer of Murine Hair Follicle MorphogenesisDevelopmental Biology, 1999
- Noggin is a mesenchymally derived stimulator of hair-follicle inductionNature Cell Biology, 1999