EFFECT OF PHOSPHATE DEPLETION ON RENAL TUBULAR REABSORPTION OF GLUCOSE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 89  (3) , 554-559
Abstract
The renal handling of glucose was evaluated in 6 dogs before and after chronic P04 depletion for 51-112 days. PO4 depletion was produced by feeding the dogs with PO4-restricted diet and administration of Al(OH)3. With PO4 depletion, serum PO4 fell from 3.5 .+-. 0.36 (SE) to 0.5 .+-. 0.19 mg/dl. Both TmG [maximum glucose transport rate] and TmG/GFR [glomerular filtration rate] fell significantly during PO4 depletion. TmG/GFR was 4.0 .+-. 0.41 mg/ml before PO4 depletion and 2.9 .+-. 0.19 mg/ml after PO4 depletion. In 4 PO4-depleted dogs TmG/GFR fell precipitously after glucose loading for more than 200 min, and practically all of the filtered glucose was excreted in the urine. It is possible that the levels of cytosolic adenine nucleotides which are required for energy of the renal cell may be reduced during PO4 depletion. This may underlie the fall in TmG and may explain the precipitous fall in TmG when the transport mechanism for glucose was operating at maximum capacity for a prolonged period of time.

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