Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales
- 1 July 2006
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Topics in Medicinal Chemistry
- Vol. 6 (14) , 1447-1456
- https://doi.org/10.2174/156802606777951073
Abstract
Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.Keywords
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