Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia
Open Access
- 1 July 1976
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 34 (1) , 53-57
- https://doi.org/10.1038/bjc.1976.121
Abstract
Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could to some extent be overcome by conjugating daunorubicin to DNA.Keywords
This publication has 7 references indexed in Scilit:
- Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemiaBritish Journal of Cancer, 1976
- Factors influencing microculture of leukaemia cellsNature, 1974
- Acute leukemia in adults.1974
- DNA-daunorubicin complex: Preliminary trials in human leukaemiaPublished by Elsevier ,1973
- Management of Adult Acute Myelogenous LeukaemiaBMJ, 1973
- Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro.1972
- Leukapheresis* by Continuous Flow Centrifugation (CFC) in Patients with Chronic Myelocytic Leukemia (CML)Blood, 1969