Transducible Peptide Therapy for Uveal Melanoma and Retinoblastoma

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Abstract
UVEAL MELANOMA and retinoblastoma are the most common primary intraocular cancers in adults and children, respectively. Current treatments for eye cancer, such as radiation and chemotherapy, are effective in many patients. However, the mechanisms of action of these modalities are nonspecific, leading to substantial injury to normal tissues and consequent dose-limiting complications.1 Molecular therapy may reduce the complications of conventional therapies by antagonizing specific molecules in cancer cells and selectively killing tumor cells with less damage to normal cells.