Percutaneous absorption of the insecticides fenitrothion and aminocarb in rats and monkeys

Publisher Website
Google Scholar
Abstract
The dermal penetration of 14 C‐ring‐labeled fenitrothion and aminocarb was determined in rats and rhesus monkeys. In monkeys, 49 ± 4% (tv2 = 14 h) of the fenitrothion and 74 ± 4% (tv2 = 25 h) of aminocarb were absorbed from the forehead, while 21 ± 70% (tv2 = 17 h) fenitrothion and 37 ± 74% (tv2 = 31 h) aminocarb were absorbed from ventral forearm. Monkey forehead was 2.3 times and 2.0 times more permeable than the forearm for fenitrothion and aminocarb, respectively. In rats, 84 ± 72% (tv2 = 20 h) of the fenitrothion and 88 ± 6% (tv2 = 17 h) aminocarb was absorbed from the middorsal region. These results were corrected for incomplete excretion by intramuscular injections of fenitrothion in money, 95 ± 7% (tv2 = 12 h), and rat, 69 ± 9% (tv2 = 12 h), and aminocarb in monkey, 95 ± 14% (tv2 = 8 h), and rat, 63 ± 6% (tv2 = 15 h). These results suggest rapid dermal absorption of these pesticides in rats and monkeys and the use of these animal models for measuring dermal penetration is discussed.

This publication has 24 references indexed in Scilit: