REVERSAL OF BETAMETHASONE-INDUCED INHIBITION OF INTESTINAL CALCIUM ABSORPTION BY 1α-HYDROXYCHOLECALCIFEROL
- 1 August 1978
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 78 (2) , 187-194
- https://doi.org/10.1677/joe.0.0780187
Abstract
SUMMARY: The intestinal absorption of calcium has been studied in conscious, unstressed pigs, using a modification of the double isotope technique. The oral administration of betamethasone (1 mg/day) to four pigs (25–33 kg) for 4 weeks reduced the calcium absorption coefficient, calculated after the intravenous and oral administration of 47Ca2+, by a mean value of 66%. The oral administration of 1α-hydroxycholecalciferol (2 μg/day) in combination with betamethasone (1 mg/day) for a further 4 weeks returned the absorption coefficient to the control value.Keywords
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