STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES
Open Access
- 1 March 1958
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 107 (3) , 383-401
- https://doi.org/10.1084/jem.107.3.383
Abstract
A substance with pyrogenic properties appears in the blood streams of rabbits made febrile by the intravenous inoculation of the PR8 strain of influenza A and Newcastle disease viruses (NDV). By means of a technique involving passive transfer of sera from animals given virus to recipient rabbits, the titer of circulating pyrogen was found to be closely correlated with the course of fever produced by virus.Keywords
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