INCREASED ALPHA-FETOPROTEIN BIOSYNTHESIS IN RATS FOLLOWING DL-ETHIONINE AND CARBON-TETRACHLORIDE INJURIES

1 January 1977

journal article
research article

Vol. 16 (1) , 163-166

Abstract

The incorporation of 14C-leucine into .alpha.-fetoprotein (AFP) in serum and liver extracts from DL-ethionine and carbon tetrachloride (CCl4)-injured rats was measured directly by using an immunochemical technique. The maximum value with nearly 10-fold increases of serum AFP was obtained in 3 days of both treatments. No significant increase in the immunoprecipitable AFP in liver extracts was detected under these conditions. [CCl4 and DL-ethionine are hepatotoxins.].

This publication has 1 reference indexed in Scilit:

MECHANISMS OF INCREASED ALPHA1-FETOPROTEIN PRODUCTION BY LIVER-INJURY .2. DIFFERENTIAL MECHANISMS OF INCREASED ALPHA1-FETOPROTEIN PRODUCTION IN RATS FOLLOWING CARBON-TETRACHLORIDE INJURY AND PARTIAL-HEPATECTOMY
1976