The Making of a Professional Secretory Cell: Architectural and Functional Changes in the ER during B Lymphocyte Plasma Cell Differentiation
- 28 January 2003
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 384 (9) , 1273-1277
- https://doi.org/10.1515/bc.2003.141
Abstract
B lymphocytes are small cells that express antigen receptors and secrete little if any IgM. Upon encounter with antigen, they differentiate into short-lived plasma cells, which secrete large amounts of polymeric IgM. Plasma cell differentiation entails a massive development of the endoplasmic reticulum to sustain high levels of Ig production. Recent findings suggest a role for the unfolded protein response in orchestrating the architectural and functional changes during terminal plasma cell differentiation.Keywords
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