EXCESSIVE PLASMA-CONCENTRATIONS OF TRICYCLIC ANTI-DEPRESSANTS RESULTING FROM USUAL DOSES - A REPORT OF 6 CASES
- 1 January 1981
- journal article
- research article
- Vol. 42 (4) , 143-147
Abstract
Six patients are described who achieved very high plasma concentrations of imipramine and desipramine during chronic therapy with usual doses. Side effects were minimal . Speculation as to apparent tolerance includes the presence of low metabolite concentrations. Plasma concentration monitoring may be indicated to identify the occasional patient who achieves potentially toxic plasma concentrations while taking recommended doses of tricyclics.This publication has 8 references indexed in Scilit:
- High‐Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2‐Hydroxylated MetabolitesJournal of Pharmaceutical Sciences, 1979
- CLINICAL CHARACTERISTICS OF IMIPRAMINE-INDUCED ORTHOSTATIC HYPOTENSIONThe Lancet, 1979
- PLASMA-LEVELS OF TRICYCLIC ANTI-DEPRESSANTS AND CLINICAL EFFICACY - REVIEW OF THE LITERATURE .2.1979
- HYDROXYLATED METABOLITES OF TRICYCLIC ANTI-DEPRESSANTS - PRE-CLINICAL ASSESSMENT OF ACTIVITY1979
- Presynaptic Alpha-Receptor Subsensitivity After Long-Term Antidepressant TreatmentScience, 1978
- Protriptyline kineticsClinical Pharmacology & Therapeutics, 1978
- Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of the anesthetized dogsEuropean Journal of Pharmacology, 1977
- Imipramine: Clinical effects and pharmacokinetic variabilityPsychopharmacology, 1977