Transfer of Experimental Panophthalmitis in Rats by Parabiosis.

Publisher Website
Google Scholar
Abstract
Summary 1. Experimental panophthalmitis has been produced in 36 of 40 rats injected with antiserum of rabbits against rat eye tissue within 24 hours after injection. Clinical and histological features of eye lesions are described. 2. Twenty-eight rats in which pathological findings were recorded by ophthalmoscopic examination after application of the antiserum (“primarily ophthalmitic animals”) were joined in parabiosis with normal animals (“originally healthy partners”) 8–43 days after injection. Three rats of the parabionts died after operation. In 21 of the remaining 25 pairs, transfer of panophthalmitis on originally healthy partners occurred between 4th and 12th day after parabiosis and the 11th and 50th day after injection of antiserum into primarily ophthalmitic animals respectively. Ophthalmoscopic and histological findings of transferred ophthalmitis were similar to those induced by injection. 3. The intervals between injection of antiserum into primarily ophthalmitic rat, parabiosis and occurrence of ophthalmitis in the originally healthy partners lead one to ask whether the panophthalmitis in the originally healthy parabionts is due to surviving injected heterologous antibodies or to some other not yet determined secondary tissue damaging factor.

This publication has 1 reference indexed in Scilit: