CD45-Positive Cells of the Retina and Their Responsiveness to In Vivo and In Vitro Treatment with IFN-γ or Anti-CD40

Abstract
Purpose. The ability to mount antigen-specific immune reactions in the retina demonstrates local recognition of retinal antigens. However, properties of antigen-presenting cells (APCs) of the retina are uncertain. The current study was undertaken to look for evidence of CD45+ cells with APC potential in the retina and to examine their in situ and in vitro responses to IFN-γ and anti-CD40, two stimuli known to upregulate activities associated with antigen presentation.

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