Catalytic Enantioselective Addition of Nitro Compounds to Imines—A Simple Approach for the Synthesis of Optically Activeβ-Nitro-α-Amino Esters
- 15 August 2001
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 40 (16) , 2992-2995
- https://doi.org/10.1002/1521-3773(20010817)40:16<2992::aid-anie2992>3.0.co;2-3
Abstract
The catalytic and asymmetric nitro‐Mannich reaction of nitro compounds to α‐imino esters catalyzed by chiral bisoxazoline–copper complexes [Eq. (1); Pg = protecting group] gave β‐nitro‐α‐amino esters with excellent diastereo‐ and enantioselectivities. The reactions can be performed under ambient conditions.Keywords
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