Age Response for CHO Cells Exposed to Negative Pions
- 1 October 1978
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 76 (1) , 219-223
- https://doi.org/10.2307/3574941
Abstract
The variation in radiosensitivity with position in the cell cycle of cultured Chinese hamster cells (line CHO) for exposures to negative pions at the peak position has been compared to the variation for X-rays. The cells were first synchronized by mitotic selection and resynchronized in the region of late G1/early S phase by treatment with hydroxyurea (10-3M). A fixed dose of 540 rad of negative pions was used to expose cells at different stages in the cell cycle. The variation (ratio of maximum survival to minimum survival) was approximately 10-fold for X-rays and 5-fold for negative pions at comparable survival levels.This publication has 2 references indexed in Scilit:
- Hydroxyurea does not prevent synchronized G1 chinese hamster cells from entering the DNA synthetic periodBiochemical and Biophysical Research Communications, 1976
- Hydroxyurea: Differential Lethal Effects on Cultured Mammalian Cells during the Cell CycleScience, 1965