Responses of blood vessels to various amines applied by microiontophoresis

Publisher Website
Google Scholar
Abstract
Various amines have been applied to arterioles of the rat intestine and mesentery by microiontophoresis. Noradrenaline produced a profound constriction with a long latency and time course. This effect was prevented by phentolamine but not by propranolol. Histamine caused a partial relaxation of noradrenaline-constricted vessels, but had no apparent action on “normal” vessels. Acetylcholine and methacholine had no apparent effect on the vessels. The results are discussed in relation to previous findings. It is suggested that the effects of microiontophoretically applied amines on blood vessels may be of importance in studies of the actions of these substances in the central nervous system using this technique.