Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences

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Abstract
Photosynthesis of previtamin D 3 can occur throughout the epidermis and in the dermis when hypopigmented Caucasian skin is exposed to solar ultraviolet radiation. Once previtamin D 3 is formed in the skin, it undergoes a temperature-dependent thermal isomerization that takes at least 3 days to complete. The vitamin D-binding protein preferentially translocates the thermal product, vitamin D 3 , into the circulation. These processes suggest a unique mechanism for the synthesis, storage, and slow, steady release of vitamin D 3 from the skin into the circulation.