Celiac disease and keratoconjunctivitis. Occurrence with thrombocytopenic purpura

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Abstract
A patient had a rare association of celiac disease, keratoconjunctivitis sicca and autoimmune thrombocytopenia. Both the malabsorption and the thrombocytopenia responded to prednisone therapy. The development of 3 different autoimmune disorders in this patient may be related to the presence of HLA-B8 and HLA-Dw3, the prevalence of which is increased in celiac disease and keratoconjunctivitis sicca, and that of HLA-B8 in autoimmune thrombocytopenic purpura. Despite the fact that thrombocytopenia is rarely encountered in celiac disease, an autoimmune mechanism should apparently be excluded in patients with this combination.

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