Absorption Efficiency and Biological Half-Life of Individual Chlorobiphenyls in Rats Treated with Kanechlor Products

Abstract
Absorption efficiency and biological half-life of individual chlorobiphenyls (PCB) contained in Kanechlor products were determined in rats. The absorption efficiencies of PCB decreased as the number of Cl atoms substituted in biphenyls increased. The absorption modes of PCB depended mainly on molecular size. The patterns of PCB decrease after oral administration were roughly classified into the monophasic, biphasic and non-decrease types. PCB with shorter biological half-lives had a P area which showed both m and p positions unsubstituted with Cl atoms in the biphenyl ring.

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