Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution
- 1 April 1994
- journal article
- review article
- Published by Springer Nature in Intensive Care Medicine
- Vol. 20 (4) , 291-297
- https://doi.org/10.1007/bf01708968
Abstract
The regulation of the distribution of ventilation/perfusion ratios by hypoxic pulmonary vasoconstriction contributes to both the efficiency of gas exchange and to pulmonary hemodynamics. In this review, the first of a two part series, are summarized the physiologic principles on which the analysis of ventilation/perfusion ratios and of pressure — flow relationships are based. A new combined analysis is introduced that permits the important contributions of hypoxic pulmonary vasoconstriction to overall gas exchange to be demonstrated in the circumstances of clinical complexity.Keywords
This publication has 25 references indexed in Scilit:
- Hypoxic Contraction of Cultured Pulmonary Vascular Smooth Muscle CellsAmerican Journal of Respiratory Cell and Molecular Biology, 1990
- Hypoxic pulmonary vasoconstriction does not affect hydrostatic pulmonary edema formationJournal of Applied Physiology, 1987
- Mechanisms of hypoxic pulmonary vasoconstriction.Published by Elsevier ,1986
- Resistance of the Pulmonary CirculationClinics in Chest Medicine, 1983
- The Effect of Cardiac Output on Arterial Blood OxygenationAnesthesiology, 1980
- Effect of chemorceptor denervation on the pulmonary vascular response to atelectasisRespiration Physiology, 1978
- Hypoxic Pulmonary Vasoconstriction and the Ratio of Hypoxic Lung to Perfused Normoxic LungAnesthesiology, 1978
- Determination of the sensitive vascular sites from which hypoxia and hypercapnia elicit rises in pulmonary arterial pressure.1968
- Effects of ventilation-perfusion inequality on elimination of inert gasesRespiration Physiology, 1967
- Alveolar Pressure, Pulmonary Venous Pressure, and the Vascular WaterfallRespiration, 1962