Flow Cytometry Followup of Patients with Low Stage Bladder Tumors

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Abstract
A total of 98 urologic outpatients with a history of conservatively treated low stage bladder tumors underwent 325 examinations during a 2-yr interval, each comprising conventional cytology, cystoscopy and automated flow cytometry. The flow cytometry results agreed with cystoscopic findings and conventional cytology in 80% of the examinations; cystoscopy and cytology agreed in 75%. Assuming cystoscopic findings were entirely accurate, the false negative rate for flow cytometry was 8.3% and the false positive rate was 5.8%. On occasion, flow cytometry diagnosis of bladder tumors antedated the development of visible tumor by up to 12 mo. Flow cytometry provided an objective and quantitative assay of epithelial abnormalities and, in the absence of skilled, conventional cytology, it appears to be a valuable new tool for the urologist in the diagnosis, management and followup of patients with bladder tumors or a history of bladder tumor.