Isolation of drugs from autopsy material by XAD-2 adsorption-elution technique a routine procedure

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Abstract
The method of adsorption of drugs on Amberlite XAD-2 resin, followed by differential elution was under study during 1 1/2 year of routine use. The method allows a separation of acidic and basic drugs and — due to acid hydrolysis step before adsorption — assures better recovery of conjugated and proteinbound drugs. The amounts of various drugs, found in autopsy cases by the XAD-2 method were usually higher than those found by solvent extraction. The method applied requires 20 g of sample (biofluid or tissue) for general toxicological analysis.