Changes of Plasma Concentrations of Interleukin-1αand Interleukin-6 with Neuroleptic Treatment for Schizophrenia

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Abstract
A significant difference of plasma interleukin (IL)-1αconcentration was found between schizophrenic patients taking neuroleptic drugs (n= 38) and those not taking them (n= 14;P< 0.02); Kruskal-Wallis analysis revealed a significant difference of plasma IL-6 concentration among the patients taking neuroleptic drugs, those not taking them, and healthy control subjects (H= 7.1, d.f. = 2,P< 0.05); also, there was a significant difference of plasma IL-6 concentration between the patients taking neuroleptic drugs (n= 32) and those not taking them (n= 13;P< 0.01). No significant differences were found between the three groups in the concentrations of IL-1β,IL-2 and tumour necrosis factor(TNF)-α.The present results suggest that neuroleptic treatment may change IL-1αand IL-6 production in schizophrenic patients.