Possible Biochemical Implications of the Crystal Structure of Biotin
- 23 January 1959
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 129 (3343) , 210
- https://doi.org/10.1126/science.129.3343.210
Abstract
An examination of the molecular architecture of biotin, as determined by x-ray crystallographic analysis, has indicated that biotin may be capable of forming an intramolecular hydrogen bond in solution. A review of various chemical analogs of the vitamin has shown a close correlation between the possibility of forming such a hydrogen bond and biotin-like activity.Keywords
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