Therapeutic Activity of Pretazettine on Rauscher Leukemia: Combination of Antiviral Activity and Cellular Protein Inhibition
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 24 (4) , 259-266
- https://doi.org/10.1159/000237790
Abstract
Pretazettine hydrochloride (PTZ) has been found to inhibit protein synthesis, without being inhibitory to DNA and RNA, in Rauscher leukemic blood cells in mice for at least 6 h after its administration. With comparison to Virazole and cycloheximide, the specific anti-Rauscher virus activity of PTZ has been demonstrated only in acutely-infected NIH/3T3 cells but not in chronically-infected cells. It is not certain that the inhibitory action of PTZ on reverse transcriptase is contributory to its therapeutic activity in leukemic mice.Keywords
This publication has 2 references indexed in Scilit:
- Fate of input oncornavirion RNA--biological studiesJournal of Virology, 1976
- Fate of interferon-treated cellsInfection and Immunity, 1976