Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa
- 1 October 2000
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (10) , 2861-2864
- https://doi.org/10.1128/aac.44.10.2861-2864.2000
Abstract
Simultaneous overexpression of MexAB-OprM and MexEF-OprN was demonstrated for a multiply antibiotic-resistant clinical isolate of Pseudomonas aeruginosa (G49). G49 also had decreased expression of OprF. No mutations in mexR or its upstream promoter region, mexT , oprM , oprF , or sigX were revealed, suggesting regulation by a hitherto undescribed locus.Keywords
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