Late Radiation Damage to Pig Skin

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Abstract
The severity of skin contraction in a previously delimited treatment field was used as a measure of late radiation damage to pig skin. Total treatment doses were given as 6, 14 and 30 fractions over 39 days or as 6 fractions over 18 days. Iso-effect curves for severe linear field contraction showed that no simple mathematical formula could be used to calculate safe tolerance doses when fractionation regimes were modified. For a given level of acute damage, late damage probably was increased by changing from 5 to 2 fractions/wk. These findings are similar to those obtained from surveys in man.