Operant behavior and subcortical drive during spreading depression.

Abstract
The influence of unilateral cortical spreading depression (SD) on lever pressing activity for electrical self-stimulation was studied in rats with chronically implanted bipolar electrodes in the lateral hypothalamic area. It could be shown that ipsilateral (with respect to side of hypothalamic stimulation) SD reduces lever pressing rates significantly more than contralateral SD. The same lateralization effect of this cortico-hypothalamic influence occurs when interference thresholds of hypothalamic stimulations during unilateral SD are compared. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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