Solitary fibrous tumors are immunophenotypically distinct from mesothelioma(s)

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Abstract
Solitary fibrous tumor is a soft tissue tissue tumor of unknown histogenesis. Based upon histologic similarities and CD‐34 expression, it has been suggested that these neoplasms bear some relationship to mesothelioma, and may represent its extra‐pleural equivalent. Methods: In order to further investigate this possible relationship, we examined a series of five dermal and five extra‐cutaneous solitary fibrous tumors with antibodies directed against the mesothelial markers calretinin and HBME‐1. Results: All the lesions failed to stain with the antibodies tested. This suggests that despite some similar histologic and immunophenotypic features, these lesions are not immunophenotypically identical. Mesotheliomas are CD‐34(+), calretinin(+), HBME‐1(+), while solitary fibrous tumors are CD‐34(+), calretinin(−), HBME‐1(−). Conclusions: The histogenesis of solitary fibrous tumor remains elusive. It is unlikely that tumor location or tumor de‐differentiation accounts for the dichotomous staining properties, as these neoplasms show a similarly benign histologic appearance regardless of location.

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