Evaluation of Two Phosphorylation Sites Improves the Prognostic Significance of Akt Activation in Non–Small-Cell Lung Cancer Tumors
- 10 January 2006
- journal article
- lung cancer
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 24 (2) , 306-314
- https://doi.org/10.1200/jco.2005.02.4133
Abstract
Purpose Akt is a serine/threonine kinase that has been implicated in lung tumorigenesis and lung cancer therapeutic resistance. Full activation of Akt requires two phosphorylation events, but only ...Keywords
This publication has 37 references indexed in Scilit:
- Prognostic Significance of Activated Akt Expression in Melanoma: A Clinicopathologic Study of 292 CasesJournal of Clinical Oncology, 2005
- Cancer Statistics, 2005CA: A Cancer Journal for Clinicians, 2005
- Phosphorylation of Akt (Ser473) is an Excellent Predictor of Poor Clinical Outcome in Prostate CancerCancer Research, 2004
- Continuing benefit of zoledronic acid for the prevention of skeletal complications in men with advanced prostate cancerJournal of Clinical Oncology, 2004
- Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle ProgressionCell Cycle, 2003
- Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cellsJournal of Clinical Investigation, 2003
- PKB Binding ProteinsCell, 2002
- Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patientsBritish Journal of Cancer, 2002
- AKT plays a central role in tumorigenesisProceedings of the National Academy of Sciences, 2001
- Revisions in the International System for Staging Lung CancerChest, 1997