Disturbances in the Reticulo-Endothelial System Following Thermal Injury

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Abstract
Previously phagocytized particulate material is released by the reticulo-endothelial system of the dog following severe thermal injury and appears in the peripheral blood in relatively large amounts. This extrusion phenomenon appears to be specific for thermal trauma and requires a scalding temperature of about 80[degree]C. Several hours after severe thermal injury the phagocytic efficiency of the liver decreases markedly. This decrease appears coincidentally with the extrusion plateau. Transfusion experiments and tissue distribution studies indicate a distinct difference between the extruded material and freshly injected colloidal chromic phosphate. Radio-autographs show the nature of this difference and indicate that the extruded material comes to lie within the polymorphonuclear leucocytes.