Propafenone-Induced Torsade de Pointes: Cross-Reactivity with Quinidine
- 1 November 1991
- journal article
- case report
- Published by Wiley in Pacing and Clinical Electrophysiology
- Vol. 14 (11) , 1568-1570
- https://doi.org/10.1111/j.1540-8159.1991.tb02729.x
Abstract
A 77-year-old female with new onset atrial fibrillation occurring in the absence of structural heart disease developed torsade de pointes during therapy with quinidine bisulfate 500 mg orally every 8 hours. Ten days after quinidine therapy had been discontinued she developed torsade de pointes while receiving propafenone 300 mg orally every 8 hours. This case demonstrates that propafenone may be associated with torsade de pointes and suggests a cross-reactivity between this effect and prior occurrence of torsade de pointes on Class IA antiarrhythmic drug therapy.Keywords
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