STUDIES ON MENINGOCOCCUS INFECTION

Open Access
Publisher Website
Google Scholar
Abstract
I. Freshly isolated strains of meningococci present a number of characteristics shown to differ not inconsiderably from those of stock strains long maintained on artificial media. Rough variants of the different types can be demonstrated, either arising spontaneously in vivo or in vitro, or evoked in the laboratory by Enders'' method. Neither freshly isolated strains (S) nor, in most cases, their R variants, are stable, both showing a tendency to pass over into the stock form or variant. Stock strains in the course of transformation from freshly isolated strains show changes in morphology and cultural characteristics, and in viability in defibrinated blood.[long dash]II. Production of monovalent sera for agglutinin or precipitin reactions with freshly isolated strains of meningococci is described. Agglutination reactions with such sera can be carried out more rapidly, at lower temp. and dilutions, than with standard monovalent sera prepared from stock cultures, while results so obtained are more satisfactory, owing to the relative absence of cross-agglutination.

This publication has 2 references indexed in Scilit: