The inhibition of low density lipoprotein oxidation by 17-alpha estradiol

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Abstract
The inhibition of LDL-oxidation by 17-alpha estradiol was assessed in vitro by the determination of the duration of the lagphase in copper ion-induced oxidation and compared to that of 17-beta estradiol, estriol, and probucol. Addition of 0.2, 0.4, and 1 umol/1 of the test substances prolonged the lag-phase of LDL-oxidation 1.3-(±0.09 SD), 1.7-(±0.14 SD), and 2.7-(±0.25 SD) fold for 17-alpha estradiol; 1.4-(±0.14 SD), 1.8-(±0.1 SD), and 2.6-(±0.16 SD) fold for 17-beta estradiol; 1.1-(±0.07 SD), 1.4-(±0.11 SD), and 1.6-(±0.11 SD) fold for estriol as well as 1.4-(±0.14 SD), 1.6-(±0.1 SD), and 3.0-(±0.21) fold for probucol, thus proving that 17-alpha estradiol is as effective as 17-beta estradiol or similar to probucol and more effective than estriol (n = 6 in all cases). These data demonstrate that 17-alpha estradiol is able to delay LDL-oxidation, hence providing a basis for clinical examination of the protective effects of 17-alpha estradiol against atherosclerosis in patients where hormonal effects of 17-beta estradiol are undesirable.

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