Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes
- 15 January 2008
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 18 (2) , 624-628
- https://doi.org/10.1016/j.bmcl.2007.11.070
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease InhibitorPLoS Medicine, 2007
- Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional SelectivityJournal of Medicinal Chemistry, 2005
- A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma bruceiPublished by Elsevier ,2004
- Crystal Structure of Human Cathepsin V,Biochemistry, 2000
- A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease proteaseStructure, 2000
- Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi InfectionThe Journal of Experimental Medicine, 1998
- Structural determinants of specificity in the cysteine protease cruzainProtein Science, 1997
- Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and LBiochemical Journal, 1996
- Vinyl Sulfones as Mechanism-Based Cysteine Protease InhibitorsJournal of Medicinal Chemistry, 1995
- The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' DiseaseJournal of Molecular Biology, 1995