Circulatory Reactions of Dogs and Rats to Polyvinylpyrrolidone or Dextran After 48/80

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Abstract
The appearance of cutaneous bluing and vaso-depression has been followed after T-1824 (Evan''s Blue) and 48/80 injection in dogs and rats subsequently challenged with polyvinylpyr-rolidone (PVP) and dextran respectively. The reverse sequence of injection was also tested. Graded doses of 48/80 in dogs resulted in refractoriness to the vasodepressive effects of similar doses, but cutaneous bluing was always seen. This increased skin capillary permeability may be interpreted as evidence of local release of histamine or other substance. In dogs it was confirmed that there is no cross protection between PVP and 48/80. In rats anesthetized with a barbiturate and pretreated with 48/80 the usual vasodepression after dextran did not occur. Rats refractory to dextran were also refractory to 48/80.

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