Observations About a Histamine Liberating Substance in Cotton Dust

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Abstract
The etiology of byssinosis and Monday-fever is still unknown. This paper describes the finding of a histamine releasing factor in extracts of cotton dust, whose biological action was much stronger than the actual histamine content of the dust. Of all the airborne dusts examined only the dust from cardrooms contained the liberating factor. In extracts of dusts containing seed fragments, sampled near the carding machines, the histamine liberating activity was many times larger than in the other extracts. There may be a relation between the histamine liberating factor in cardroom dust and the dyspnoeic Monday-feeling of cardroom workers.

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