CYTOPLASMIC AND NUCLEAR ESTROGEN AND PROGESTERONE RECEPTORS IN MALE BREAST-CANCER

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (11) , 4812-4814
Abstract
Cytoplasmic estrogen receptors were detected in 12 of 13 male breast cancer tumors. There was no significant correlation of receptor levels with the age of the patient, size and histological grading of the tumor, and stage and nodal involvement of the disease. Nuclear estrogen receptors were found in 8 of 10 tumors and 6 of 9 patients had tumors positive for cytoplasmic progesterone receptors, 2 of which contained nuclear progesterone receptors. The presence of cytoplasmic progesterone receptors, in addition to cytoplasmic and nuclear estrogen receptors, may be indicative of truly hormone-dependent tumors in male breast cancer. Treatment offered to patients included surgery, X-ray therapy, chemotherapy and orchiectomy, but no general conclusions of the efficacy of the therapeutic regime can be drawn.