Nephrotic syndrome associated with methimazole therapy
- 1 February 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 139 (2) , 236-237
- https://doi.org/10.1001/archinte.139.2.236
Abstract
Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. The development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves'' disease is reported. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, it is proposed that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.This publication has 0 references indexed in Scilit: