Effects of Interferon on Vesicular Stomatitis Virus Transcription and Translation

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Abstract
The effect of interferon [human] on the synthesis of the RNA species and proteins of vesicular stomatitis virus was studied in 2 cell types [rhesus monkey kidney LLC-MK2 and human amnion U cells]. Virus protein synthesis is inhibited by interferon despite the apparent presence of near normal amounts of virus RNA with sedimentation values characteristic of virus mRNA. The synthesis of those virus RNA species which are completely dependent on virus protein synthesis is preferentially inhibited in interferon-treated cells. These results are most consistent with a model of interferon action postulating a primary effect on translation of virus mRNA.