Diastereofacial selectivity in the intramolecular conjugate addition of a nitrogen nucleophile; stereocontrolled piperidine synthesis
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1523-1524
- https://doi.org/10.1039/c39870001523
Abstract
Complementary and high diastereoselection is readily achieved by changing the geometry of the double bond in the base-induced cyclization of acyclic unsaturated amine derivatives (2), leading to the stereodivergent synthesis of 2,3-disubstituted piperidines.Keywords
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