Preliminary Note on the Preparation of Non-toxic Shiga Dysentery Vaccines by Irradiation with Soft X-rays

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Abstract
A non-toxic vaccine of Shigella dysenteriae was prepared by irradiating conc. saline suspensions of the organisms with soft x-rays, the most intense part of which consisted of the K[alpha](1.54 A) and the K[beta] (1.38 A) lines of copper. The x-ray tube was operated at 38 peak kilovolts and 20 m.a. The time of irradiation varied from 30 to 300 min. Vaccines receiving large doses of x-rays were rendered non-toxic and retained their antigenic properties; vaccines receiving small doses of x-rays, even though these doses were more than sufficient to kill the organisms, were still toxic.

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