In Vivo and in Vitro Blood–Brain Barrier Transport of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors
- 1 January 1994
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 11 (2) , 305-311
- https://doi.org/10.1023/a:1018975928974
Abstract
Among the HMG-CoA reductase inhibitors, lovastatin and simvastatin have central nervous system (CNS) side effects, such as sleep disturbance, whereas pravastatin does not. This difference in CNS side...Keywords
This publication has 14 references indexed in Scilit:
- Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and SimvastatinJournal of Pharmaceutical Sciences, 1991
- Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells.1991
- Inhibitors of hydroxymethylglutaryl coenzyme A reductase for treating hypercholesterolaemia.BMJ, 1990
- COMPARISON OF INVITRO AND INVIVO MODELS OF DRUG TRANSCYTOSIS THROUGH THE BLOOD-BRAIN-BARRIER1990
- Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term CultureJournal of Neurochemistry, 1989
- HMG-CoA Reductase Inhibitors for HypercholesterolemiaNew England Journal of Medicine, 1988
- Atenolol versus pindolol: Side-effects in hypertensionEuropean Journal of Clinical Pharmacology, 1985
- CNS-related side-effects with metoprolol and atenololEuropean Journal of Clinical Pharmacology, 1985
- An in situ brain perfusion technique to study cerebrovascular transport in the ratAmerican Journal of Physiology-Heart and Circulatory Physiology, 1984
- Regulation of HMG-CoA ReductasePublished by Elsevier ,1976