DYE-MEDIATED PHOTOLYSIS OF HUMAN NEUROBLASTOMA-CELLS - IMPLICATIONS FOR AUTOLOGOUS BONE-MARROW TRANSPLANTATION
- 1 July 1986
- journal article
- research article
- Vol. 68 (1) , 32-36
Abstract
Cells from three different human neuroblastoma cell lines and normal human bone marrow cells were exposed to the lipophilic fluorescent dye, merocyanine 540 (MC 540), and white light. In vitro clonogenic tumor cells were inactivated up to 25,000 times more rapidly than multipotent hematopoietic progenitor cells (CFU-GEMM). It is conceivable that this pronounced difference in sensitivity to MC 540-mediated photolysis can be exploited for the selective killing of residual neuroblastoma cells in autologous remission marrow grafts.This publication has 14 references indexed in Scilit:
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