THE INFLUENCE OF VARIOUS PHYSIOLOGICAL SUBSTANCES ON THE GLYCOGENOLYSIS OF SURVIVING RAT LIVER1

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Abstract
Lesser''s method of estimating the "diastatic efficiency" of frog liver lobes was modified for warm blooded animals by determining the 60 min. decrease in glycogen of rat liver slices surviving in a buffer soln. at 37[degree]C. The effect on this system of various concs. of 2 bile-salt preps. containing different proportions'' of Na glycocholate and taurocholate was studied in 62 expts. By expressing the "bile-salt glycogenolysis" in terms of + and [long dash]deviations from "bile-salt-free glycogenolysis" a biphasic curve in bile-salt glycogenolysis was obtained. The positive phase of this curve occurred at low concs., the negative phase at high concs. The physiological action of the surface-active bile salts on the intracellular fixation of the glycogenase to the protein boundary structures of the liver cells is discussed. The relationships of the findings to Forsgren''s daily cycle of the liver function, artificial and pathologic obstructive jaundice, and von Gierke''s glycogen storage disease is considered.

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