De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold
- 15 February 2005
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 15 (4) , 1161-1164
- https://doi.org/10.1016/j.bmcl.2004.12.007
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Modulating T cell responses for the treatment of psoriasis: a focus on efalizumabExpert Opinion on Biological Therapy, 2003
- Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin RegulationPublished by Elsevier ,2003
- Integrin activation and structural rearrangementImmunological Reviews, 2002
- Mechanisms contributing to the activity of integrins on leukocytesImmunological Reviews, 2002
- Anti-adhesion antibodiesTransplant Immunology, 2002
- Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical PropertiesJournal of Medicinal Chemistry, 2001
- Inhibitors of LFA-1/ICAM-1 interaction: From monoclonal antibodies to small moleculesDrugs of the Future, 2001
- The Leukocyte IntegrinsJournal of Biological Chemistry, 2000
- Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. CohenJournal of Molecular Biology, 1999
- A fluorometric assay for the quantitation of cell adherence to endothelial cellsJournal of Immunological Methods, 1993