Characteristics of an Antigen Reactivity in Synovial Fluids and Its Association with Rheumatoid Arthritis

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Abstract
Summary When antisera to RA synovial fibroblasts were reacted with synovial fluids in immunoelectrophoretic analyses, 90% of RA fluids gave a wing or extended precipi-tin arc pattern. In contrast, 38% of non-RA fluids gave the same types of patterns. The characteristics of the antigen are different from other previously reported synovial fluid components or antigens, and the antigen appears to be a glycoprotein. This study was supported by Grants AM-16326 and AM-10728 from the National Institutes of Health, by a grant from the Illinois Chapter of the Arthritis Foundation, a Clinical Research Center Grant from the Arthritis Foundation, and by Allied Health Professions Advanced Traineeship Grant No. 1-A02-AH00428-01. B. Anderson is the recipient of Research Career Development Award No. AM-70787 from NIH.